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Association details:
| Biomarker: | GOLGA4-JAK2 fusion |
|---|---|
| Cancer: | B Acute Lymphoblastic Leukemia |
| Drug Class: | JAK inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Identification of a novel GOLGA4–JAK2 fusion gene in B-cell acute lymphoblastic leukaemia
Published date:
10/25/2021
Excerpt:
...sequencing identified a novel GOLGA4–JAK2 fusion gene...Cells expressing GOLGA4-JAK2 demonstrated constitutive activation of JAK/STAT signalling and were sensitive to JAK inhibitors...JAK2 fusion genes identified in B-ALL and supports the incorporation of JAK inhibitors into treatment strategies to improve outcomes for this subtype.
DOI:
https://doi.org/10.1111/bjh.17910
