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Association details:
| Biomarker: | GNAQ Q209P |
|---|---|
| Cancer: | Uveal Melanoma |
| Drug: | REC-4881 (MEK1 inhibitor, MEK2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines
Excerpt:
The five uveal melanoma cell lines had GNAQ or GNA11 mutations and were either moderately or highly sensitive to TAK733….All five uveal melanoma cell lines were sensitive to TAK733 with IC50 values below 10 nM, with three of them being highly sensitive. All these cell lines carried GNAQ or GNA11 driver mutations (Figure (Figure11 and Table Table1).
DOI:
10.1186/1476-4598-11-22
