^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma

Excerpt:
...Mel202 (accession number JN184779) and 92.1 (accession number JN184780) carry a mutation at codon 209 of GNAQ while the remaining cell lines are wild type for GNAQ....UM cells that harbor GNAQ mutations are more sensitive to the anitproliferative activity of enzastaurin....A, UM cell lines used in the present study. B, enzastaurin exhibited greater antiproliferative effects on UM cell lines carrying GNAQ mutations (MT) than those with wild type GNAQ (WT).
DOI:
10.1371/journal.pone.0029622