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Association details:
| Biomarker: | GNAQ Q209P |
|---|---|
| Cancer: | Melanoma |
| Drug: | CI-1040 (MEK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition
Excerpt:
When GNAQQ209P was expressed in A375 cells….Oncogenic GNAQ contributes to BRAFi resistance. Graph showing A375P and 22 092 cell growth in the presence of increasing concentrations of PLX4720 and PD184352.
DOI:
10.1093/annonc/mdu049
