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Association details:
| Biomarker: | GNAQ Q209L |
|---|---|
| Cancer: | Uveal Melanoma |
| Drug: | FR900359 (Gαq-11 protein inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma
Excerpt:
In the present study, we show that FR effectively inhibits signaling in UM cells expressing Gαq-Q209L, Gαq-Q209P and Gα11-Q209L….In summary, the data presented here show that FR inhibits oncogenic Gαq/11-Q209 protein in vitro and in UM cells, promoting cell cycle arrest and eventual cell death, while also preventing the colonization of UM cells in 3D culture.
DOI:
10.1158/1541-7786.MCR-18-0574
