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Association details:
| Biomarker: | GJA1 overexpression |
|---|---|
| Cancer: | Glioma |
| Drug: | temozolomide (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide
Published date:
02/25/2021
Excerpt:
The role of exosomal connexin 43 (Cx43) in the resistance of glioma cells to TMZ and cell migration was investigated....higher expression levels of Cx43 were detected in TMZ‑resistant U251 (U251r) cells compared with those in TMZ‑sensitive (U251s) cells....found that the expression of Cx43 in rExo was notably higher compared with that in sExo, whereas treatment with rExo increased the expression of Cx43 in U251s cells.
DOI:
10.3892/or.2021.7995
