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Association details:
| Biomarker: | GH1 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | OBI-999 (Microtubule inhibitor, Globo H-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 5946: OBI-999, an anti-Globo H antibody drug conjugate, exhibits synergistic anti-tumor effect in combination with pembrolizumab
Published date:
04/04/2023
Excerpt:
In the high GH expression human breast cancer cell line HCC-1428 xenograft model, OBI-999+pembrolizumab exhibited significantly stronger inhibition of tumor growth compared to either OBI-999 or pembrolizumab alone….The results suggest that combination therapy with OBI-999 and immune checkpoint inhibitors is warranted in human clinical studies.
DOI:
https://doi.org/10.1158/1538-7445.AM2023-5946
