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Association details:
| Biomarker: | GFI1 36N |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | temozolomide (DNA synthesis inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1048 Impeding DNA Repair Offers a Novel Possibility for Personalized Therapy in AML Patients, Who Are Carrier of the Growth Factor Independence 1 Variant “GFI1-36N”
Published date:
11/04/2020
Excerpt:
When treated alone, a low dose of TMZ negatively affected proliferation and differentiation of murine GFI1-36N leukemic cells but not in non-leukemic cells and GFI1-36S leukemic cells (IC50=38.01 vs 287.20 µg/ml.
