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Association details:
| Biomarker: | GATA1 overexpression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | imatinib (c-KIT inhibitor, Bcr-abl tyrosine kinase inhibitor, PDGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
CLINICAL SIGNIFICANCE OF GATA1, GATA2 AND TAL1 EXPRESSION SIGNATURES IN ACUTE MYELOID LEUKEMIA.
Published date:
06/12/2020
Excerpt:
...GATA1 overexpression decreased sensitivity of AML cells to RTK-inhibitor Imatinib and cytotoxic drug Cytarabine, but increased response to SRC-inhibitor Bosutinib…
