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Association details:
| Biomarker: | GAS5 underexpression |
|---|---|
| Cancer: | Prostate Cancer |
| Drug Class: | mTOR inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells
Excerpt:
First generation mTORC1, combined mTORC1/mTORC2 and dual PI3K/mTOR inhibitors all increased cellular GAS5 levels and inhibited culture growth in androgen-dependent (LNCaP) and androgen-sensitive (22Rv1) cell lines, but not in androgen-independent (PC-3 and DU 145) cell lines. The latter exhibited low endogenous GAS5 expression, and GAS5 silencing in LNCaP and 22Rv1 cells decreased the sensitivity to mTOR inhibitors...
DOI:
10.1002/pros.22952