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Association details:
| Biomarker: | GAS1 underexpression |
|---|---|
| Cancer: | Basal Cell Carcinoma |
| Drug: | Erivedge (vismodegib) (Hedgehog cell-signalling pathway inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Gene-Related Response of Basal Cell Carcinoma to Biologic Treatment with Vismodegib
Published date:
01/27/2020
Excerpt:
Molecular analysis revealed that the mean level of expression of GAS1 was significantly lower in the patients with a complete response compared to the patients with a partial response: 1874.83 ± 905.26 vs. 3901 ± 420.05, respectively (P = 0.014)....The baseline expression level of GAS1 appears to be predictive of the response of locally advanced BCC to systemic Vismodegib treatment.
DOI:
10.1038/s41598-020-58117-0
