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    Association details:
    Biomarker:FOXM1 overexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:adavosertib (AZD1775) (WEE1 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    J Thorac Dis
    Title:

    Overexpressed FOXM1 collaborates with MMB to increase WEE1 inhibitor sensitivity in NSCLC

    Published date:
    06/30/2023
    Excerpt:
    It was demonstrated that after AZD-1775 treatment, the decrease in cell survival mediated by FOXM1 overexpression (P<0.001)...In this study, we verified that overexpression of FOXM1 induces DNA replication stress and stimulates DNA repair responses, thereby sensitizing cells to AZD1775.
    DOI:
    10.21037/jtd-23-750