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Association details:
| Biomarker: | FOXC1 expression |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | doxorubicin hydrochloride (Topoisomerase II inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers
Published date:
10/14/2020
Excerpt:
...we demonstrated that the expression of FOXC1 was associated with resistance of doxorubicin treatment of breast cancer cells. In conclusion, these results suggest that FOXC1 may be a potential biomarker or drug target for TNBCs, and that downregulation of FOXC1 could have therapeutic value in treatment of TNBCs.
DOI:
10.1038/s41401-020-00543-x