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Association details:
| Biomarker: | FOXA3 overexpression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | sorafenib (Multi-tyrosine kinase inhibitor, pan-RAF inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
m6A RNA methylation-mediated HNF3? reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance
Published date:
12/26/2020
Excerpt:
Kaplan–Meier analysis revealed that patients with high HNF3γ levels in the resected HCCs exhibited a better OS after adjuvant sorafenib treatment than the patients with low HCC HNF3γ levels...
DOI:
10.1038/s41392-020-00299-0
