Reversal of Acquired Drug Resistance in FLT3-mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies
Excerpt:
...combining the type I TK inhibitor crenolanib with the type II TK inhibitor sorafenib in sorafenib-resistant cells. This combination showed profound synergistic pro-apoptotic effects even at 10-fold lower concentrations than the growth inhibitory concentrations of crenolanib as single agent treatment.