^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Reversal of Acquired Drug Resistance in FLT3-mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies

Excerpt:
...combining the type I TK inhibitor crenolanib with the type II TK inhibitor sorafenib in sorafenib-resistant cells. This combination showed profound synergistic pro-apoptotic effects even at 10-fold lower concentrations than the growth inhibitory concentrations of crenolanib as single agent treatment.
DOI:
https://dx.doi.org/10.1158%2F1078-0432.CCR-13-2052