^
Association details:
| Biomarker: | FLT3 V592_D593INSDFREY |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | sunitinib (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
An Innovative Phase I Clinical Study Demonstrates Inhibition of FLT3 Phosphorylation by SU11248 in Acute Myeloid Leukemia Patients
Excerpt:
FLT3 genotype analysis was performed in all patients on entry to the study. The observed incidence of FLT3-ITD (exon 14) mutations was 10.3% [3 of 29; VDFREYE (592–598), KYFYVDFRE (588–596), and DFREY (593–597) in patients 3, 4, and 10, respectively]….All patients who exhibited strong FLT3 inhibition at doses <200 mg were FLT3 mutant. SU11248 inhibited FLT3 phosphorylation in all five FLT3 mutant cases. IP/W analysis of FLT3 phosphorylation in ITD patients 3 and 10...
DOI:
10.1038/sj.onc.1206543
