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Association details:
Biomarker:FLT3 overexpression
Cancer:Prostate Cancer
Drug:Zejula (niraparib) (PARP inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Title:

Phase I Study of Niraparib in Combination with Radium-223 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

Published date:
11/02/2022
Excerpt:
Thirty patients were treated with niraparib and radium-223...Whole blood gene expression of PAX5 and CD19 were higher in responders and ARG-1, IL-2R and FLT3 expression were higher in non-responders.
Secondary therapy:
radium Ra-223 dichloride
DOI:
10.1158/1078-0432.CCR-22-2526