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Association details:
| Biomarker: | FLT3 N676D |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | sorafenib (Multi-tyrosine kinase inhibitor, pan-RAF inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Reversal of Acquired Drug Resistance in FLT3-mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies
Excerpt:
...sorafenib resistant cell line Ba/F3-ITD-Res developed by long-term exposure of Ba/F3-ITD cells to low doses of sorafenib in vitro, and identified N676D and Y842C mutations in TKD1 and TKD2, respectively...
DOI:
https://dx.doi.org/10.1158%2F1078-0432.CCR-13-2052
