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Association details:
| Biomarker: | FLT3 G846S |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Sutent (sunitinib) (c-KIT inhibitor, VEGFR inhibitor, PDGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
An Innovative Phase I Clinical Study Demonstrates Inhibition of FLT3 Phosphorylation by SU11248 in Acute Myeloid Leukemia Patients
Excerpt:
In addition, a novel activation loop mutation, G846S (exon 20), was identified in patient 22. Patients were also genotyped for mutations in KIT, another SU11248 target….These data clearly demonstrate that a single dose of SU11248 results in inhibition of FLT3 phosphorylation in a dose-dependent manner in AML patients, with inhibition in all genotypes.
DOI:
10.1038/sj.onc.1206543
