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Association details:
| Biomarker: | FLT3 G697R |
|---|---|
| Cancer: | Chronic Myeloid Leukemia |
| Drug: | Rydapt (midostaurin) (Multi-tyrosine kinase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Prediction of Resistance to Small Molecule FLT3 Inhibitors
Excerpt:
Given the high-level resistance of the G697R mutant to PKC412….All of these inhibitors potently inhibited the growth of Ba/F3 cells expressing FLT3-ITD, and growth inhibition correlated with inhibition of FLT3 phosphorylation (Fig. 4 ⇓ ; data not shown). In contrast, none of these inhibitors potently inhibited the growth of Ba/F3 cells expressing the G697R mutant.
DOI:
10.1158/0008-5472.CAN-04-2148
