Given the high-level resistance of the G697R mutant to PKC412….All of these inhibitors potently inhibited the growth of Ba/F3 cells expressing FLT3-ITD, and growth inhibition correlated with inhibition of FLT3 phosphorylation (Fig. 4 ⇓ ; data not shown). In contrast, none of these inhibitors potently inhibited the growth of Ba/F3 cells expressing the G697R mutant.