^
Association details:
Biomarker:FLT3 G697R
Cancer:Acute Myelogenous Leukemia
Drug:D-65476 (FLT3 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Source:
Title:

Prediction of Resistance to Small Molecule FLT3 Inhibitors

Excerpt:
Given the high-level resistance of the G697R mutant to PKC412….All of these inhibitors potently inhibited the growth of Ba/F3 cells expressing FLT3-ITD, and growth inhibition correlated with inhibition of FLT3 phosphorylation (Fig. 4 ⇓ ; data not shown). In contrast, none of these inhibitors potently inhibited the growth of Ba/F3 cells expressing the G697R mutant.
DOI:
10.1158/0008-5472.CAN-04-2148