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Association details:
| Biomarker: | FLT3 F691L |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Turalio (pexidartinib) (c-KIT inhibitor, FLT3 inhibitor, AKT inhibitor, CSF-1R inhibitor, FMS kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Characterizing and Overriding the Structural Mechanism of the Quizartinib-resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397
Excerpt:
We performed proliferation studies of PLX3397 and quizartinib for Ba/F3 cells expressing FLT3-ITD and FLT3-ITD/F691L and confirmed that PLX3397, in contrast to quizartinib, has the ability to inhibit the proliferation of both isoforms...
DOI:
10.1158/2159-8290.CD-15-0060
