^
    Back
    Association details:
    Biomarker:FLT3 D835
    Cancer:Acute Myelogenous Leukemia
    Drug:LAM 003 (HSP90 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    ASH 2019
    Title:

    LAM-003, a Novel Oral Heat Shock Protein 90 Inhibitor for Treatment of Acute Myeloid Leukemia, Including Wild-Type and FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Disease

    Published date:
    11/06/2019
    Excerpt:
    ...primary AML blasts harboring a D835 mutation displayed sensitivity to LAM-003 when tested ex vivo.
    DOI:
    https://doi.org/10.1182/blood-2019-125770