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Association details:
| Biomarker: | FLT3 D698N |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | FF-10101 (FLT3 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
FF-10101 Retains Potent Inhibitory Activities Against Resistant Mutations to FLT3 Inhibitors, Newly Identified in Random Mutagenesis Screens
Published date:
11/06/2019
Excerpt:
FF-10101 (GI50, 0.73 nM), quizartinib (GI50, 0.99 nM) and crenolanib (GI50, 19 nM) retained potency against FLT3-ITD+D698N, while midostaurin (GI50, 47 nM) did not have a potency.
DOI:
https://doi.org/10.1182/blood-2019-124632
