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Association details:
| Biomarker: | FLCN deletion |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | Opsiria (sirolimus) (mTOR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
Excerpt:
...sirolimus could effectively inhibit Flcn-deficient allograft tumor growth, suggesting that mTOR inhibitors may be effective in treating FLCN-deficient RCC. Additionally, we demonstrated that a higher dose of sirolimus and earlier treatment delivered a better suppressive effect on tumor growth, showing a dose-dependent manner in tumor suppression.
DOI:
10.18632/oncotarget.5018
