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    Association details:
    Biomarker:FIP1L1-PDGFRA fusion
    Cancer:Chronic Eosinophilic Leukemia
    Drug:imatinib (YD312) (c-KIT inhibitor, SCF signal transduction pathway inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    Source:
    ATS 2021
    Title:

    Chronic Eosinophilic Leukemia Presenting as Asthma

    Published date:
    04/04/2021
    Excerpt:
    A 72-year-old man with...a diagnosis of FIP1L1-PDGFRA positive chronic hypereosinophilic leukemia...was also initiated imatinib 400mg daily by hematology and at two months he had markedly decreased eosinophilia (6.5% of WBC of 7.4) with improved respiratory symptoms . Repeat spirometry demonstrated resolution of obstructive airway disease...