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Association details:
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Source:
Title:

Fibroblast growth factor receptor 4 increases epidermal growth factor receptor (EGFR) signaling by inducing amphiregulin expression and attenuates response to EGFR inhibitors in colon cancer

Published date:
07/20/2020
Excerpt:
...we examined the expression of FGFR4 and AREG in patients with metastatic colon cancer who received cetuximab combination chemotherapy as a first line of treatment...patients with higher expression of FGFR4 or AREG showed significantly poor OS compared to patients with low expression of these proteins...
Secondary therapy:
Chemotherapy
DOI:
10.1111/cas.14526