^
Association details:
| Biomarker: | FGFR4 overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Erbitux (cetuximab) (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Fibroblast growth factor receptor 4 increases epidermal growth factor receptor (EGFR) signaling by inducing amphiregulin expression and attenuates response to EGFR inhibitors in colon cancer
Published date:
07/20/2020
Excerpt:
...we examined the expression of FGFR4 and AREG in patients with metastatic colon cancer who received cetuximab combination chemotherapy as a first line of treatment...patients with higher expression of FGFR4 or AREG showed significantly poor OS compared to patients with low expression of these proteins...
Secondary therapy:
Chemotherapy
DOI:
10.1111/cas.14526
