^
Association details:
Biomarker:FGFR4 overexpression
Cancer:Breast Cancer
Drug Class:FGFR inhibitor
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

High FGFR1-4 mRNA expression levels correlate with response to selective FGFR inhibitors in breast cancer

Published date:
09/30/2021
Excerpt:
We evaluated the antitumor activity of an FGFRi and an MTKI in a collection of seventeen BC patient-derived xenografts (PDXs) harboring amplification in FGFR1/2/3/4 and in ten patients receiving either an FGFRi/MTKI....High FGFR1-4 mRNA levels but not copy number alteration (CNA) associated with FGFRi response.
DOI:
0.1158/1078-0432.CCR-21-1810