^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Published date:
03/24/2017
Excerpt:
In xenografts from human tumor cell lines or patient-derived tumor tissue with activating FGFR alterations, JNJ-42756493 administration results in potent and dose-dependent antitumor activity accompanied by pharmacodynamic modulation of phospho-FGFR and phospho-ERK in tumors.
DOI:
10.1158/1535-7163.MCT-16-0589