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    Association details:
    Biomarker:FGFR4 expression
    Cancer:Ovarian Cancer
    Drug:Avastin (bevacizumab) (VEGF-A inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: B - Late Trials
    Source:
    Lab Invest
    Title:

    Fibroblast Growth Factor Receptors and Ligands in Context of Bevacizumab Response in Ovarian Carcinoma: An Exploratory Analysis of AGO-OVAR 11/ICON-7

    Published date:
    12/27/2023
    Excerpt:
    In this exploratory analysis of tissue samples from the pivotal, prospective, randomized phase III AGO-OVAR 11/ICON-7 trial (NCT00483782), we investigate the prognostic and predictive potential of FGFR/FGF expression (FGFR1, FGFR2, FGFR3, and FGFR4 or their ligands, FGF1 and FGF19)....expression of FGFR4 and FGF19 was linked to more favorable outcomes.
    DOI:
    https://doi.org/10.1016/j.labinv.2023.100321
    Trial ID:
    ICON-7