^
Association details:
| Biomarker: | FGFR4 amplification |
|---|---|
| Cancer: | Clear Cell Renal Cell Carcinoma |
| Drug: | BLU 9931 (FGFR4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Fibroblast growth factor receptor type 4 as a potential therapeutic target in clear cell renal cell carcinoma
Published date:
02/20/2023
Excerpt:
...all ccRCC cell lines (A498, A704, 769-P, and 786-O) harboured an FGFR4 copy number amplification...To investigate the anti-cancer effect of BLU9931 in vivo, we subcutaneously implanted mice with A498 xenografts….The tumour size decreased 3 days after the initiation of treatment. The two treatment groups showed similar results, compared with the control groups. A significant difference in tumour volume between the 30 mg/kg and 100 mg/kg groups was observed on days 10 and 8, respectively...
DOI:
https://doi.org/10.1186/s12885-023-10638-3
