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Association details:
| Biomarker: | FGFR3 V555M |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | PD173074 (Tyrosine kinase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance
Published date:
06/20/2013
Excerpt:
Sequencing of FGFR3 in KMS-11R cells revealed the presence of a heterozygous mutation at the gatekeeper residue, encoding FGFR3V555M; consistent with this, KMS-11R cells were cross-resistant to AZD4547 and PD173074.
DOI:
10.1038/onc.2012.319
