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Association details:
| Biomarker: | FGFR3 S249C |
|---|---|
| Cancer: | Urothelial Cancer |
| Drug: | PD173074 (Tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance
Excerpt:
...FGFR3 protein levels were high in 97–7 cells, moderate in RT4 and RT112 cells, and low in 97–29 and T24 cells (Figure 2a); of these, 97–7 and 97–29 cells express FGFR3S249C….PD173074 inhibited the proliferation of 97–7, RT4 and RT112, causing a G1 cell cycle arrest, but had little effect on 97–29 cells and no effect on T24 cells...
DOI:
https://doi.org/10.1038/onc.2012.319
