^
Association details:
| Biomarker: | FGFR3 S249C |
|---|---|
| Cancer: | Urothelial Cancer |
| Drug: | fexagratinib (ABSK091) (FGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance
Excerpt:
...FGFR3 protein levels were high in 97–7 cells, moderate in RT4 and RT112 cells, and low in 97–29 and T24 cells (Figure 2a); of these, 97–7 and 97–29 cells express FGFR3S249C….Both AZ8010 and AZD4547 inhibited the proliferation of 97–7 and RT4 cells (Figures 2b and c). The 97–7 and RT4 cells responded to AZD4547 with a dose-dependent G1 cell cycle arrest with no evidence of cell death (Figure 2d).
DOI:
https://doi.org/10.1038/onc.2012.319
