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Association details:
| Biomarker: | FGFR3 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug Class: | FGFR inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
High FGFR1-4 mRNA expression levels correlate with response to selective FGFR inhibitors in breast cancer
Published date:
09/30/2021
Excerpt:
We evaluated the antitumor activity of an FGFRi and an MTKI in a collection of seventeen BC patient-derived xenografts (PDXs) harboring amplification in FGFR1/2/3/4 and in ten patients receiving either an FGFRi/MTKI....High FGFR1-4 mRNA levels but not copy number alteration (CNA) associated with FGFRi response.
DOI:
10.1158/1078-0432.CCR-21-1810
