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Association details:
| Biomarker: | FGFR3 K650 |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | Rydapt (midostaurin) (Multi-tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies
Excerpt:
...PKC412 effectively inhibited the growth of FGFR3 TDII-and TEL-FGFR3-transformed Ba/F3 cells in the absence of IL-3 with a cellular IC50 of ∼240 and 200 nM, respectively...
