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Association details:
| Biomarker: | FGFR2b expression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | GB2102 (FGFR2b inhibitor, FGF7 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
LB539 - Development of GB2102, a novel and highly differentiated anti-FGFR2b antibody for the treatment of gastric cancer
Published date:
03/09/2022
Excerpt:
GB2102 induced potent ADCC effects by primary human NK cells to kill FGFR2b-expressing tumor cells…preclinical studies showed that GB2102 is an anti-FGFR2b antibody with potent ADCC effect and strong FGF7 blocking but weak FGF10 inhibition. These results suggest that GB2102 is potentially a safe and effective candidate for the treatment of FGFR2b positive gastric cancer.
