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Association details:
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
New
Title:

TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma

Excerpt:
...a 59-year-old female with a FGFR2-ZMYM4 fusion-positive ICC who presented with a dominant 15 cm liver mass and metastases to her liver and lungs...Upon next line TAS-120 treatment, she achieved stable disease with a best response of +8%. Progression occurred at approximately 7 months, with a mixed response consisting of rebound growth of a previously responsive lung lesion, stability of the dominant mass, and continued progression of the biopsied left lobe liver lesion.
DOI:
https://dx.doi.org/10.1158%2F2159-8290.CD-19-0182