...a 43 year-old white female who underwent a right salpingo-oophorectomy and endometrial ablation in the context of a ruptured ovarian cyst...Pathological evaluation of the liver mass was consistent with a moderately differentiated intrahepatic cholangiocarcinoma...Transcriptome analysis revealed the presence of an FGFR2-TACC3 fusion...She had been treated with pazopanib 800 mg orally daily for 4 months and demonstrated tumor shrinkage...She remains on therapy approximately 4 months since the initiation of ponatinib. As such, anti-tumor activity was obtained with two distinct FGFR inhibitors in the same patient.