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Association details:
| Biomarker: | FGFR2 N550K |
|---|---|
| Cancer: | Endometrial Cancer |
| Drug: | PD173074 (Tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Inhibition of Activated Fibroblast Growth Factor Receptor 2 in Endometrial Cancer Cells Induces Cell Death Despite PTEN Abrogation
Excerpt:
Six endometrial cancer cell lines (two mutant N550K FGFR2 and four WT FGFR2) were treated with increasing concentrations of PD173074...the two endometrial cancer cell lines with mutant FGFR2 (AN3CA and MFE296) were 10 to 40 times more sensitive to inhibition with PD173074 than cell lines with WT FGFR2.
DOI:
10.1158/0008-5472.CAN-08-0770
