A 59-yr-old male presented clinically with abdominal pain and fullness...Surgical pathology confirmed intrahepatic cholangiocarcinoma, which was staged as T2aN0...the patient underwent a repeat tumor biopsy and RNA profiling of his cancer using an NGS assay, OSU-SpARKFuse (Reeser et al. 2017), which revealed a novel gene fusion involving FGFR2 (exons 1–16) and CLIP1 (exons 19–24)...After a total of 5 mo (7 cycles) on INCB054828, CT scans showed a 41.3% increase in size of the two target lesions confirming progressive disease...