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Association details:
| Biomarker: | FGFR2 amplification |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | Balversa (erdafitinib) (pan-FGFR inhib) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor
Excerpt:
Animals bearing xenograft tumors derived from SNU-16 human gastric cancer cells harboring FGFR2 amplifications were treated orally with vehicle or JNJ-42756493 at various doses...Nevertheless, JNJ-42756493 resulted in dose-dependent tumor growth inhibition (TGI) in SNU-16 tumor-bearing mice.
DOI:
10.1158/1535-7163.MCT-16-0589