^
Association details:
| Biomarker: | FGFR2 amplification |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Iclusig (ponatinib) (Multi-tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Ponatinib (AP24534), a Multitargeted Pan-FGFR Inhibitor with Activity in Multiple FGFR-Amplified or Mutated Cancer Models
Excerpt:
FGFR2 has been found to be amplified and overexpressed in the colon cancer cell line H716 (13). We found that ponatinib potently inhibited the growth of H716 cells with a GI50 value of 7 nmol/L but did not affect the growth of Colo205 cells (430 nmol/L; Fig. 5D) that lack constitutive FGFR2 phosphorylation...
DOI:
10.1158/1535-7163.MCT-11-0450
