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    Association details:
    Biomarker:FGFR1 V561M
    Cancer:Non Small Cell Lung Cancer
    Drug:fexagratinib (ABSK091) (FGFR inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Mol Cancer Res
    Title:

    The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT

    Excerpt:
    ...validated our findings using a non-small cell lung cancer cell line, H1581, engineered to overexpress WT or V561M FGFR1….cells expressing V561M demonstrate dramatic resistance to AZD4547 driven by increased STAT3 activation downstream of V561M FGFR1.
    DOI:
    10.1158/1541-7786.MCR-18-0429