...a 46-year-old man who presented with a locally advanced pancreatic head mass consistent with PDAC...Additional genetic alterations included a homozygous CDKN2A deletion, TP53 splice site mutation (c.994-1G>C), SMAD4 nonsense mutation (c.247C>T, p.Q83*), and FGFR1 missense mutation (c.422C>G, p.T141R). The patient was treated with crizotinib alone, but experienced progression after 2 months, with development of leptomeningeal disease and secondary spinal cord compression.