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Association details:
| Biomarker: | FGFR1 rearrangement + Chr t(8;13) |
|---|---|
| Cancer: | Lymphoma |
| Drug: | Pemazyre (pemigatinib) (FGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Myeloid/lymphoid neoplasm with FGFR1 rearrangement
Published date:
09/09/2021
Excerpt:
A 25-year-old man presented...cytometry analysis confirmed involvement by T-lymphoblastic leukemia/lymphoma...An FGFR1 (8p11) gene rearrangement was detected in the lymph node...Cytogenetics revealed t(8;13) in the bone marrow (panel D)...Newer TKIs and small molecule FGFR1 inhibitors (pemigatinib; clinical trial FIGHT-203) may be effective bridging therapies to stem cell transplant.
DOI:
https://doi.org/10.1182/blood.2021012168
