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    Association details:
    Biomarker:FGFR1 overexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:M6123 (FGFR1 antagonist)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Eur J Cancer
    Title:

    FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response

    Published date:
    05/10/2021
    Excerpt:
    ...NSCLC PDX models demonstrating FGFR1 amplification and FGFR1 protein overexpression were sensitive to M6123. 
    DOI:
    10.1016/j.ejca.2021.04.005