^
Association details:
| Biomarker: | FGFR1 overexpression |
|---|---|
| Cancer: | Lung Non-Small Cell Squamous Cancer |
| Drug: | PRN1371 (FGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance
Excerpt:
Tumor-bearing mice were orally dosed with vehicle or PRN1371 at a dose of 15 mg/kg b.i.d. Significant tumor growth inhibition was observed in three of the four squamous NSCLC PDX models (Table 3).
DOI:
10.1158/1535-7163.MCT-17-0309
