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Association details:
| Biomarker: | FGFR overexpression |
|---|---|
| Cancer: | Hepatocellular Cancer |
| Drug: | WXSH0011 (FGFR inhibitor, c-MET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical evaluation of WXSH0011, a selective small molecule dual inhibitor of FGFR/c-Met.
Published date:
05/28/2020
Excerpt:
The antitumor activity of WXSH0011 was evaluated in vivo cell derived-xenograft (CDX) models of Gastric Cancer SNU-16 and HCC Hep3B….WXSH0011 inhibited cell proliferation in FGFR overexpressed NCl-H1581, SNU-16, RT112/84, Hep3B with IC50 10 nM, 3 nM, 2 nM, 63 nM,...
DOI:
10.1200/JCO.2020.38.15_suppl.e15641
