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Association details:
| Biomarker: | FGFR mutation |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | tasurgratinib (E7090) (FGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models
Excerpt:
To evaluate the effect of E7090 on survival, we established a lung metastasis model using 4T1, a mouse breast cancer cell line...Daily administration of E7090 significantly prolonged the survival of mice in the 12.5 to 50 mg/kg dosing groups.
DOI:
10.1158/1535-7163.MCT-16-0261
